Extensive Genomic Plasticity in Pseudomonas aeruginosa Revealed by Identification and Distribution Studies of Novel Genes among Clinical Isolates
K Shen, S Sayeed, P Antalis, J Gladitz… - Infection and …, 2006 - Am Soc Microbiol
The distributed genome hypothesis (DGH) states that each strain within a bacterial species
receives a unique distribution of genes from a population-based supragenome that is many
times larger than the genome of any given strain. The observations that natural infecting
populations are often polyclonal and that most chronic bacterial pathogens have highly
developed mechanisms for horizontal gene transfer suggested the DGH and provided the
means and the mechanisms to explain how chronic infections persist in the face of a …
receives a unique distribution of genes from a population-based supragenome that is many
times larger than the genome of any given strain. The observations that natural infecting
populations are often polyclonal and that most chronic bacterial pathogens have highly
developed mechanisms for horizontal gene transfer suggested the DGH and provided the
means and the mechanisms to explain how chronic infections persist in the face of a …
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